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Research & education only — not financial advice.TENK is not a registered investment adviser; calls are impersonal, generated from SEC filings and a delayed/third-party price feed, and may be wrong or out of date. The operator and an affiliated trading operation may hold or trade the securities TENK rates — see Disclosures. Do your own research.

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Home›Stocks›XLO
XLO logo

XLO

Xilio Therapeutics, Inc.

Last earnings +0.0% on 2026-05-12

Hold
$9.15
▼ -1.29%
$9.15▼ -3.17%
over 1Y
L $7.14H $12.08
Earnings Dividend Split Congress buy Congress sellGrouped by date · hover a pin to expand
Today-1.3%
1W+2.9%
1M+11.6%
3M+7.5%
YTD-2.7%
1Y-3.2%
OverviewFinancialsValuationQualityTimelineFilings
Rating
Hold
Quality
C
Valuation
Fair value
Filings
Clean
Hold
Conviction
Horizon
Long (>12mo)
Street · 5 analysts
Buy

Trades near cash with AbbVie/Gilead deals validating the platform, but it's a pre-revenue-drug biotech fresh off a 1-for-14 reverse split.

Cash & equivalents $138M · FY2025

Xilio is a clinical-stage oncology company with no approved product; its FY2025 revenue of $43.8M (up 589.9%) is collaboration and license income from its AbbVie collaboration and Gilead license, not durable product sales, so the headline growth rate overstates the underlying business. The company remains deeply unprofitable — operating income of -$42.0M (-95.9% margin), net loss of -$35.0M, and a -99.3% ROE against an accumulated deficit of -$419M. This is a binary, catalyst-driven story where the fundamentals will be set by trial data, not by extrapolating the income statement.

The balance sheet is the reason this isn't an outright avoid. Cash of $138M sits against a market cap of just $52.9M, and reported FY2025 operating cash burn was only -$4.99M because collaboration upfronts largely offset the $56.0M gross R&D spend. That said, total liabilities of $119M (3.39x equity) — much of which is likely deferred collaboration revenue rather than debt — leave net cash of roughly $19M, so the 'trading below cash' hook is real on gross cash but thinner on a net basis. The $36.2M of potential Series C warrant proceeds is contingent on the stock clearing the $10.50 exercise price, above today's $9.15.

AI-generated analysis, produced by our proprietary engine from SEC filing data.

Investment recommendation produced by TENK/calls (tenkcalls.com), Luxembourg. Completed Jul 3, 2026, 12:47 PM ET. Ratings & methodology: definitions · All recommendations to date: track record · Conflicts: disclosures. Not investment advice.

Is XLO a buy? The one-page verdict, explained →

Financials · annual, by fiscal year

Line itemFY21FY22FY23FY24FY25
Revenue———$6.34M$43.8M
Gross profit—————
Operating income-$75.0M-$89.1M-$79.1M-$60.6M-$42.0M
Net income-$75.8M-$88.2M-$76.4M-$58.2M-$35.0M
Diluted EPS-$13.52-$3.22-$2.78-$15.24-$4.19
Net margin———-918.0%-80.1%

Annual figures from SEC 10-K XBRL filings. Open the filing links below for full statement detail.

Key statistics

Valuation

Enterprise value-$77.4M
EV / EBITDA—
EV / Sales-1.8
EV / FCF—
P / FCF—
PEG (trailing)—
Earnings yield-58.2%
FCF yield-9.2%

Quality & risk

ROIC (est.)-94.0%
Free cash flow-$5.51M
Total debt—
Net cash$138M
Altman Z-Score-3.41 distress
Piotroski F-Score5/7

Capital returns

Buyback yield—
Dividend yield (est.)—
Shareholder yield—
Shares Δ YoY-88.8%

Computed from SEC XBRL annual figures + the current quote. EV and ROIC use long-term + current debt where filed; estimates, not investment advice.

Disclosure timeline

SEC · 8-Ks + reports
Recent disclosure tone has been improving.
  1. 8-K Officer / director change2026-06-12

    Annual meeting votes certified; board/officer change disclosed (Items 5.02, 5.07)

  2. S-3/A Shelf registration (potential raise)2026-05-27
  3. 8-K Earnings results2026-05-12

    Q1 2026 10-Q: strong cash balance and collab revenue, R&D losses continue

  4. S-3 Shelf registration (potential raise)2026-05-12

    Q1 2026 10-Q: strong cash balance and collab revenue, R&D losses continue

  5. 10-Q Quarterly report2026-05-12

    Q1 2026 10-Q: strong cash balance and collab revenue, R&D losses continue

  6. DEF 14A Proxy statement2026-04-28
  7. 8-K Officer / director change2026-04-16

    Executive/board leadership change disclosed (Item 5.02)

  8. 8-K Earnings results2026-03-23

    FY2025 10-K: revenue $43.8M (+590%), loss narrowed, $138M cash, reverse split

  9. 10-K Annual report2026-03-23

    FY2025 10-K: revenue $43.8M (+590%), loss narrowed, $138M cash, reverse split

Recent filings

all on EDGAR ↗
4Period ending 2026-06-112026-06-12open ↗4Period ending 2026-06-112026-06-12open ↗4Period ending 2026-06-112026-06-12open ↗4Period ending 2026-06-112026-06-12open ↗4Period ending 2026-06-112026-06-12open ↗4Period ending 2026-06-112026-06-12open ↗4Period ending 2026-06-112026-06-12open ↗8-KPeriod ending 2026-06-102026-06-12open ↗EFFECTFiling2026-05-29open ↗S-3/AFiling2026-05-27open ↗SCHEDULE 13GFiling2026-05-15open ↗SCHEDULE 13G/AFiling2026-05-15open ↗

Quality score

C
ValueGrowthProfitHealthMom.
ValueA-
GrowthA+
ProfitabilityF
Financial healthC-
MomentumD
  • ✓Revenue growing year-over-year
  • ✗Profitable (positive net income)
  • ✗Net margin above 10%
  • ✗Return on equity above 15%
  • ✗Liabilities below 2× equity
7.1452-week12.08
Revenue
$43.8M
+589.9% YoY
Net margin
-80.1%
ROE
-99.3%
P/E
—

SEC fundamentals · FY 2025

'21'22'23'24'25

■ revenue · ■ net income, by fiscal year

Revenue$43.8M+589.9%
Net income-$35.0M+39.8%
Operating income-$42.0M+30.7%
Diluted EPS-$4.19+72.5%
Cash & equivalents$138M+148.7%
Total assets$155M+117.6%
Total liabilities$119M+123.3%
Stockholders' equity$35.3M+100.4%
Op.: -95.9%L/E: 3.39x

Frequently asked

Is Xilio Therapeutics, Inc. (XLO) a buy?
XLO currently carries a Hold rating with 2/5 conviction, derived from its latest SEC filings. Trades near cash with AbbVie/Gilead deals validating the platform, but it's a pre-revenue-drug biotech fresh off a 1-for-14 reverse split.
What is Xilio Therapeutics, Inc.'s quality score?
XLO scores 57.693030153011186/100 (grade C) on a SEC-grounded quality model spanning value, growth, profitability, financial health and momentum.

Sources: SEC EDGAR (CIK 0001840233, latest 10-Q filed 2026-05-12) · EODHD · Proprietary analysis · as of 7/3/2026, 4:47:25 PM.

Research and education only — not financial advice. TENKis not a registered investment adviser or broker-dealer and gives no personalized advice. Every call is impersonal — identical for all users, generated on a schedule from SEC filings plus a delayed/third-party price feed — may be wrong or out of date, and is not a recommendation to buy or sell any security. The operator and an affiliated trading operation may hold or trade the securities TENK rates; see Disclosures. Past performance does not guarantee future results. Do your own research.

Earnings history

beat/miss · move
2026-05-12Beat +13.0% est▲ 0.00%8-K ↗
2026-03-23Beat +147.7% est▲ 0.00%8-K ↗
2026-01-08Beat +147.7% est▲ +2.70%8-K ↗
2025-11-13Beat +80.2% est▼ -9.18%8-K ↗
2025-08-14Miss -98.0% est▼ -1.68%8-K ↗
2025-05-08—▲ +7.95%8-K ↗

Dates from 8-K (Item 2.02); beat/miss = reported EPS vs consensus (Finnhub, recent quarters); move = prior close → close on/after.

Recent news

market news →
Xilio Therapeutics Appoints Ben Harshbarger as Chief Legal OfficerBullish
globenewswire.com· 2026-06-29
Cancer Stocks That Are Advancing the Future of Oncology CareBullish
finance.yahoo.com· 2026-05-18
Xilio Therapeutics Reports First Quarter 2026 Financial Results and Provides Pipeline and Business UpdatesBullish
globenewswire.com· 2026-05-12
Xilio Therapeutics Reports First Quarter 2026 Financial Results and Provides Pipeline and Business UpdatesBullish
finance.yahoo.com· 2026-05-12
Xilio Therapeutics Announces Inducement Grants Under Nasdaq Listing Rule 5635(c)(4)Bullish
globenewswire.com· 2026-05-07
Most and least shorted small-to-mid-cap stocksBullish
seekingalpha.com· 2026-04-06

Vs tracked universe

compare →

1195 tracked peers · median

TENK Score58 vs 67
Revenue growth589.9% vs 7.5%
Net margin-80.1% vs 10.0%
Return on equity-99.3% vs 12.0%
P/E— vs 26.2

News sentiment

EODHD · 4d
Bullish
+0.16
vs typical · 5 articles
↑ improving

Recent news tone vs the market's typical (which skews positive). A soft signal, not a recommendation.