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Research & education only — not financial advice.TENK is not a registered investment adviser; calls are impersonal, generated from SEC filings and a delayed/third-party price feed, and may be wrong or out of date. The operator and an affiliated trading operation may hold or trade the securities TENK rates — see Disclosures. Do your own research.

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TTENK/calls
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Home›UPB›Financials
Annual statements · SEC XBRL · FY2023 – FY2025

Upstream Bio, Inc. (UPB) financials

Income statement

Upstream Bio, Inc. (UPB) income statement, annual, from SEC filings
Fiscal yearFY2023FY2024FY2025
Revenue$2.38M$2.37M$2.85M
Revenue growth—-0.4%20.4%
Operating income-$40.1M-$77.8M-$160M
Operating margin-1685.5%-3281.2%-5618.8%
Net income-$20.5M-$62.8M-$143M
Net margin-862.9%-2650.0%-5026.0%
EPS (diluted)-$12.95-$5.58-$2.66

Cash flow

Upstream Bio, Inc. (UPB) cash flow, annual, from SEC filings
Fiscal yearFY2023FY2024FY2025
Operating cash flow-$37.9M-$59.2M-$133M
Capital expenditures$144K$511K$165K
Free cash flow-$38.1M-$59.7M-$133M

Balance sheet

Upstream Bio, Inc. (UPB) balance sheet, annual, from SEC filings
Fiscal yearFY2023FY2024FY2025
Cash & equivalents$25.8M$326M$102M
Total assets$117M$482M$354M
Total liabilities$9.39M$11.9M$14.0M
Shareholders' equity-$123M$470M$340M
Retained earnings-$128M-$191M-$334M
Shares (wtd avg diluted)2.95M13.7M53.9M

Every figure is extracted from Upstream Bio, Inc.’s annual reports as filed with the SEC (XBRL company facts) — no third-party estimates. Fiscal years are labeled by period end; filers occasionally re-tag concepts, so a sparse cell means the company didn’t report that concept for that year. Free cash flow = operating cash flow − capital expenditures.

Common questions

What is Upstream Bio, Inc.'s annual revenue?
Upstream Bio, Inc. (UPB) reported $2.85M of revenue for fiscal year 2025 — up 20.4% from $2.37M in FY2024, per its annual report filed with the SEC.
Is Upstream Bio, Inc. profitable?
Not in FY2025 — UPB reported a net loss of $143M, per SEC filings.
What is Upstream Bio, Inc.'s free cash flow?
-$133M in FY2025 (operating cash flow -$133M minus $165K of capital expenditures), from the SEC cash-flow statement.
Does UPB pay a dividend?
Upstream Bio, Inc. reported no cash dividends paid in FY2025, per its SEC cash-flow statement.
Full UPB analysis — verdict, score & filings →Is UPB a buy? →

Research and education only — not financial advice. TENKis not a registered investment adviser or broker-dealer and gives no personalized advice. Every call is impersonal — identical for all users, generated on a schedule from SEC filings plus a delayed/third-party price feed — may be wrong or out of date, and is not a recommendation to buy or sell any security. The operator and an affiliated trading operation may hold or trade the securities TENK rates; see Disclosures. Past performance does not guarantee future results. Do your own research.