As of the latest Form 4 filed Jul 9, 2026.
What Ionis Pharmaceuticals Inc insiders — officers, directors and 10% owners — have bought and sold in their own stock, straight from their SEC Form 4 filings. Values are shares × the reported transaction price where both are disclosed.
Buys plotted up, sells down; bar height is the disclosed dollar value (shares × reported price). Our Form 4 history is only complete from mid-2026, so early months are sparse — the series fills in as more filings land. Open-market purchases and sales only.
Newest filing first — the 114 most recent filings for IONS.
| Filed | Trade date | Insider | Transaction | Shares | Price | Value | 10b5-1 | Filing |
|---|---|---|---|---|---|---|---|---|
| 2026-07-09 | 2026-07-07 | BENNETT C FRANK EVP, Chief Scientific Officer | SSale | −15.0K | $85.46 | $1.28M | Yes (planned) | Form 4 ↗ |
| 2026-07-09 | 2026-07-07 | BENNETT C FRANK, EVP, Chief Scientific Officer | JOther | +15.0K | $0.00 | $0.00 | Yes (planned) | Form 4 ↗ |
| 2026-07-09 | 2026-07-07 | BENNETT C FRANK, EVP, Chief Scientific Officer | SSale | −5.54K | $83.58 | $463K | Yes (planned) | Form 4 ↗ |
| 2026-07-09 | 2026-07-07 | Diaz Allene M. Director | SSale | −10.1K | $85.42 | $864K | Yes (planned) | Form 4 ↗ |
| 2026-07-09 | 2026-07-07 | Diaz Allene M., Director | MExercise | +10.1K | $47.11 | $476K | Yes (planned) | Form 4 ↗ |
| 2026-07-09 | 2026-07-07 | Kordasiewicz Holly B. EVP, Chief Development Officer | SSale | −362.00 | $84.30 | $30.5K | Yes (planned) | Form 4 ↗ |
| 2026-07-06 | 2026-07-01 | KLEIN JOSEPH III Director | SSale | −11.4K | $79.04 | $903K | Yes (planned) | Form 4 ↗ |
| 2026-07-06 | 2026-07-01 | KLEIN JOSEPH III, Director | SSale | −99.00 | $79.45 | $7.87K | Yes (planned) | Form 4 ↗ |
| 2026-07-06 | 2026-07-01 | KLEIN JOSEPH III, Director | MExercise | +11.5K | $39.94 | $460K | Yes (planned) | Form 4 ↗ |
| 2026-06-30 | 2026-06-26 | Baroldi Joseph EVP, Chief Business Officer | SSale | −5.63K | $80.16 | $452K | Yes (planned) | Form 4 ↗ |
| 2026-06-30 | 2026-06-26 | Baroldi Joseph, EVP, Chief Business Officer | MExercise | +1.77K | $32.60 | $57.7K | Yes (planned) | Form 4 ↗ |
| 2026-06-30 | 2026-06-26 | Baroldi Joseph, EVP, Chief Business Officer | MExercise | +3.87K | $56.78 | $220K | Yes (planned) | Form 4 ↗ |
| 2026-06-30 | 2026-06-26 | O'NEIL PATRICK R. EVP CLO & General Counsel | SSale | −3.07K | $80.00 | $246K | Yes (planned) | Form 4 ↗ |
| 2026-06-30 | 2026-06-26 | Schneider Eugene EVP, Chf Clinical Develop Ofcr | SSale | −26.0K | $81.05 | $2.11M | Yes (planned) | Form 4 ↗ |
| 2026-06-30 | 2026-06-26 | Schneider Eugene, EVP, Chf Clinical Develop Ofcr | MExercise | +26.0K | $60.89 | $1.58M | Yes (planned) | Form 4 ↗ |
| 2026-06-26 | 2026-06-26 | Monia Brett P Chief Executive Officer | SSale | −50.0K | $80.59 | $4.03M | Yes (planned) | Form 4 ↗ |
| 2026-06-26 | 2026-06-26 | Monia Brett P, Chief Executive Officer | MExercise | +50.0K | $56.78 | $2.84M | Yes (planned) | Form 4 ↗ |
| 2026-06-26 | 2026-06-25 | Monia Brett P, Chief Executive Officer | SSale | −21.1K | $78.49 | $1.65M | Yes (planned) | Form 4 ↗ |
| 2026-06-26 | 2026-06-25 | Monia Brett P, Chief Executive Officer | MExercise | +21.1K | $32.60 | $687K | Yes (planned) | Form 4 ↗ |
| 2026-06-26 | 2026-06-25 | Swayze Eric EVP Research | SSale | −10.6K | $79.18 | $839K | Yes (planned) | Form 4 ↗ |
| 2026-06-26 | 2026-06-24 | Monia Brett P Chief Executive Officer | SSale | −14.6K | $78.41 | $1.14M | Yes (planned) | Form 4 ↗ |
| 2026-06-26 | 2026-06-24 | Monia Brett P, Chief Executive Officer | MExercise | +14.6K | $32.60 | $475K | Yes (planned) | Form 4 ↗ |
| 2026-06-16 | 2026-06-15 | BERTHELSEN SPENCER R Director | SSale | −8.00K | $73.49 | $588K | Yes (planned) | Form 4 ↗ |
| 2026-06-16 | 2026-06-15 | BERTHELSEN SPENCER R, Director | MExercise | +8.00K | $24.42 | $195K | Yes (planned) | Form 4 ↗ |
| 2026-06-16 | 2026-06-12 | Kordasiewicz Holly B. EVP, Chief Development Officer | SSale | −19.8K | $74.05 | $1.47M | Yes (planned) | Form 4 ↗ |
| 2026-06-16 | 2026-06-12 | Kordasiewicz Holly B., EVP, Chief Development Officer | SSale | −41.0K | $73.09 | $3.00M | Yes (planned) | Form 4 ↗ |
| 2026-06-16 | 2026-06-12 | Kordasiewicz Holly B., EVP, Chief Development Officer | MExercise | +19.9K | $56.78 | $1.13M | Yes (planned) | Form 4 ↗ |
| 2026-06-16 | 2026-06-12 | Kordasiewicz Holly B., EVP, Chief Development Officer | MExercise | +12.0K | $32.60 | $391K | Yes (planned) | Form 4 ↗ |
| 2026-06-16 | 2026-06-12 | Kordasiewicz Holly B., EVP, Chief Development Officer | MExercise | +21.0K | $60.89 | $1.28M | Yes (planned) | Form 4 ↗ |
| 2026-06-16 | 2026-06-12 | Kordasiewicz Holly B., EVP, Chief Development Officer | MExercise | +7.95K | $60.89 | $484K | Yes (planned) | Form 4 ↗ |
| 2026-06-03 | 2026-06-01 | BERTHELSEN SPENCER R Director | SSale | −8.00K | $75.67 | $605K | Yes (planned) | Form 4 ↗ |
| 2026-06-03 | 2026-06-01 | BERTHELSEN SPENCER R, Director | MExercise | +8.00K | $24.42 | $195K | Yes (planned) | Form 4 ↗ |
| 2026-05-15 | 2026-05-14 | Monia Brett P Chief Executive Officer | SSale | −3.22K | $78.68 | $253K | Yes (planned) | Form 4 ↗ |
| 2026-05-15 | 2026-05-14 | Monia Brett P, Chief Executive Officer | MExercise | +3.22K | $32.60 | $105K | Yes (planned) | Form 4 ↗ |
| 2026-05-15 | 2026-05-13 | Monia Brett P, Chief Executive Officer | SSale | −1.32K | $78.01 | $103K | Yes (planned) | Form 4 ↗ |
| 2026-05-15 | 2026-05-13 | Monia Brett P, Chief Executive Officer | MExercise | +1.32K | $32.60 | $42.9K | Yes (planned) | Form 4 ↗ |
| 2026-05-06 | 2026-05-04 | LOSCALZO JOSEPH Director | SSale | −17.8K | $75.58 | $1.34M | Yes (planned) | Form 4 ↗ |
| 2026-05-06 | 2026-05-04 | LOSCALZO JOSEPH, Director | SSale | −59.5K | $74.90 | $4.46M | Yes (planned) | Form 4 ↗ |
| 2026-05-06 | 2026-05-04 | LOSCALZO JOSEPH, Director | MExercise | +16.0K | $64.80 | $1.04M | Yes (planned) | Form 4 ↗ |
| 2026-05-06 | 2026-05-04 | LOSCALZO JOSEPH, Director | MExercise | +12.0K | $60.20 | $722K | Yes (planned) | Form 4 ↗ |
| 2026-05-06 | 2026-05-04 | LOSCALZO JOSEPH, Director | MExercise | +16.0K | $42.88 | $686K | Yes (planned) | Form 4 ↗ |
| 2026-05-06 | 2026-05-04 | LOSCALZO JOSEPH, Director | MExercise | +10.3K | $41.08 | $424K | Yes (planned) | Form 4 ↗ |
| 2026-05-06 | 2026-05-04 | LOSCALZO JOSEPH, Director | MExercise | +12.0K | $40.05 | $481K | Yes (planned) | Form 4 ↗ |
| 2026-05-06 | 2026-05-04 | LOSCALZO JOSEPH, Director | MExercise | +11.0K | $38.06 | $417K | Yes (planned) | Form 4 ↗ |
| 2026-05-05 | 2026-05-01 | KLEIN JOSEPH III Director | SSale | −1.43K | $74.45 | $107K | Yes (planned) | Form 4 ↗ |
| 2026-05-05 | 2026-05-01 | KLEIN JOSEPH III, Director | SSale | −8.68K | $73.35 | $637K | Yes (planned) | Form 4 ↗ |
| 2026-05-05 | 2026-05-01 | KLEIN JOSEPH III, Director | MExercise | +10.1K | $47.11 | $476K | Yes (planned) | Form 4 ↗ |
| 2026-04-30 | 2026-04-28 | Baroldi Joseph EVP, Chief Business Officer | SSale | −1.63K | $71.79 | $117K | Yes (planned) | Form 4 ↗ |
| 2026-04-17 | 2026-04-16 | Jenne Kyle EVP, Chf GL Pdt Str Ofcr | SSale | −4.90K | $75.17 | $368K | No | Form 4 ↗ |
| 2026-04-17 | 2026-04-16 | Birchler Brian EVP, Corp and Development Ops | SSale | −973.00 | $75.04 | $73.0K | No | Form 4 ↗ |
| 2026-04-17 | 2026-04-16 | Baroldi Joseph EVP, Chief Business Officer | SSale | −5.62K | $74.56 | $419K | No | Form 4 ↗ |
| 2026-04-17 | 2026-04-15 | PARSHALL B LYNNE Director | SSale | −534.00 | $76.97 | $41.1K | Yes (planned) | Form 4 ↗ |
| 2026-04-17 | 2026-04-15 | PARSHALL B LYNNE, Director | SSale | −4.47K | $76.19 | $340K | Yes (planned) | Form 4 ↗ |
| 2026-04-17 | 2026-04-15 | Jenne Kyle EVP, Chf GL Pdt Str Ofcr | MExercise | +12.2K | $0.00 | $0.00 | No | Form 4 ↗ |
| 2026-04-17 | 2026-04-15 | Birchler Brian EVP, Corp and Development Ops | MExercise | +1.88K | $0.00 | $0.00 | No | Form 4 ↗ |
| 2026-04-17 | 2026-04-15 | Baroldi Joseph EVP, Chief Business Officer | MExercise | +10.8K | $0.00 | $0.00 | No | Form 4 ↗ |
| 2026-03-23 | 2026-03-19 | Schneider Eugene EVP, Chf Clinical Develop Ofcr | SSale | −5.81K | $70.97 | $412K | Yes (planned) | Form 4 ↗ |
| 2026-03-18 | 2026-03-17 | HOUGEN ELIZABETH L EVP, Finance & CFO | SSale | −10.2K | $73.21 | $745K | Yes (planned) | Form 4 ↗ |
| 2026-03-18 | 2026-03-16 | HOUGEN ELIZABETH L, EVP, Finance & CFO | SSale | −9.44K | $72.77 | $687K | Yes (planned) | Form 4 ↗ |
| 2026-03-18 | 2026-03-16 | HOUGEN ELIZABETH L, EVP, Finance & CFO | SSale | −206K | $72.38 | $14.9M | Yes (planned) | Form 4 ↗ |
| 2026-03-18 | 2026-03-16 | HOUGEN ELIZABETH L, EVP, Finance & CFO | MExercise | +20.5K | $37.58 | $772K | Yes (planned) | Form 4 ↗ |
| 2026-03-18 | 2026-03-16 | HOUGEN ELIZABETH L, EVP, Finance & CFO | MExercise | +33.1K | $32.60 | $1.08M | Yes (planned) | Form 4 ↗ |
| 2026-03-18 | 2026-03-16 | HOUGEN ELIZABETH L, EVP, Finance & CFO | MExercise | +61.0K | $56.78 | $3.47M | Yes (planned) | Form 4 ↗ |
| 2026-03-18 | 2026-03-16 | HOUGEN ELIZABETH L, EVP, Finance & CFO | MExercise | +60.3K | $60.89 | $3.67M | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-10 | Monia Brett P Chief Executive Officer | SSale | −17.6K | $76.34 | $1.34M | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-10 | Monia Brett P, Chief Executive Officer | SSale | −16.5K | $75.47 | $1.25M | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-10 | Monia Brett P, Chief Executive Officer | MExercise | +34.1K | $60.89 | $2.08M | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-10 | Jenne Kyle EVP, Chf GL Pdt Str Ofcr | MExercise | +4.67K | $34.69 | $162K | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-10 | Jenne Kyle, EVP, Chf GL Pdt Str Ofcr | SSale | −16.1K | $76.30 | $1.23M | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-10 | Jenne Kyle, EVP, Chf GL Pdt Str Ofcr | SSale | −21.2K | $75.50 | $1.60M | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-10 | Jenne Kyle, EVP, Chf GL Pdt Str Ofcr | MExercise | +32.6K | $46.10 | $1.50M | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-09 | O'NEIL PATRICK R. EVP CLO & General Counsel | SSale | −10.1K | $75.25 | $764K | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-09 | Monia Brett P Chief Executive Officer | SSale | −1.68K | $75.58 | $127K | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-09 | Monia Brett P, Chief Executive Officer | SSale | −118K | $75.26 | $8.85M | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-09 | Monia Brett P, Chief Executive Officer | SSale | −7.38K | $74.11 | $547K | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-09 | Monia Brett P, Chief Executive Officer | MExercise | +73.5K | $60.89 | $4.48M | Yes (planned) | Form 4 ↗ |
| 2026-03-11 | 2026-03-09 | Monia Brett P, Chief Executive Officer | MExercise | +40.8K | $60.89 | $2.49M | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-04 | LOSCALZO JOSEPH Director | SSale | −200.00 | $80.00 | $16.0K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-04 | LOSCALZO JOSEPH, Director | MExercise | +200.00 | $38.06 | $7.61K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-04 | Baroldi Joseph EVP, Chief Business Officer | SSale | −201.00 | $80.00 | $16.1K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-04 | Baroldi Joseph, EVP, Chief Business Officer | MExercise | +201.00 | $32.60 | $6.55K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-04 | Baroldi Joseph, EVP, Chief Business Officer | SSale | −238.00 | $80.00 | $19.0K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-04 | Baroldi Joseph, EVP, Chief Business Officer | MExercise | +238.00 | $56.78 | $13.5K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | LOSCALZO JOSEPH Director | SSale | −832.00 | $80.33 | $66.8K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | LOSCALZO JOSEPH, Director | MExercise | +832.00 | $38.06 | $31.7K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | KLEIN JOSEPH III Director | SSale | −1.01K | $80.82 | $81.8K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | KLEIN JOSEPH III, Director | SSale | −6.79K | $80.00 | $543K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | KLEIN JOSEPH III, Director | SSale | −13.5K | $79.17 | $1.07M | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | KLEIN JOSEPH III, Director | MExercise | +4.00K | $42.88 | $172K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | KLEIN JOSEPH III, Director | MExercise | +12.0K | $40.05 | $481K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Diaz Allene M. Director | SSale | −1.00K | $80.80 | $81.2K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Diaz Allene M., Director | SSale | −14.6K | $79.88 | $1.17M | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Diaz Allene M., Director | SSale | −39.3K | $79.11 | $3.11M | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Diaz Allene M., Director | MExercise | +18.0K | $40.05 | $721K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Diaz Allene M., Director | MExercise | +12.0K | $38.06 | $457K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Diaz Allene M., Director | MExercise | +10.3K | $41.08 | $424K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Devers Shannon L. EVP, Chief Human Resources Ofc | SSale | −755.00 | $80.84 | $61.0K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Devers Shannon L., EVP, Chief Human Resources Ofc | SSale | −5.03K | $80.00 | $402K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Devers Shannon L., EVP, Chief Human Resources Ofc | SSale | −14.3K | $79.12 | $1.13M | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Devers Shannon L., EVP, Chief Human Resources Ofc | MExercise | +385.00 | $52.87 | $20.4K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Devers Shannon L., EVP, Chief Human Resources Ofc | MExercise | +6.95K | $32.60 | $227K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Devers Shannon L., EVP, Chief Human Resources Ofc | MExercise | +5.50K | $34.69 | $191K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Devers Shannon L., EVP, Chief Human Resources Ofc | MExercise | +3.76K | $40.85 | $154K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Devers Shannon L., EVP, Chief Human Resources Ofc | MExercise | +3.51K | $37.58 | $132K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | BENNETT C FRANK EVP, Chief Scientific Officer | SSale | −802.00 | $80.76 | $64.8K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | BENNETT C FRANK, EVP, Chief Scientific Officer | SSale | −12.7K | $79.88 | $1.01M | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | BENNETT C FRANK, EVP, Chief Scientific Officer | SSale | −71.6K | $79.10 | $5.66M | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | BENNETT C FRANK, EVP, Chief Scientific Officer | MExercise | +48.6K | $60.89 | $2.96M | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | BENNETT C FRANK, EVP, Chief Scientific Officer | MExercise | +16.5K | $32.60 | $537K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Baroldi Joseph EVP, Chief Business Officer | SSale | −36.00 | $81.01 | $2.92K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Baroldi Joseph, EVP, Chief Business Officer | SSale | −2.09K | $80.41 | $168K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Baroldi Joseph, EVP, Chief Business Officer | MExercise | +879.00 | $32.60 | $28.7K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Baroldi Joseph, EVP, Chief Business Officer | MExercise | +820.00 | $56.78 | $46.6K | Yes (planned) | Form 4 ↗ |
| 2026-03-05 | 2026-03-03 | Baroldi Joseph, EVP, Chief Business Officer | SSale | −4.10K | $79.36 | $325K | Yes (planned) | Form 4 ↗ |
Insiders — a company’s officers, directors and holders of more than 10% of its stock — must report any trade in that stock to the SEC on a Form 4 within two business days. Each row here is one transaction from those filings.
The transaction code tells you what happened: Purchase (P) and Sale (S) are open-market trades — the ones markets watch most; Award (A) is a granted stock or unit, Option exercise (M) converts options into shares, and Gift (G) is a transfer for no consideration. Awards, exercises and gifts are largely compensation or administrative, not a directional bet.
One caveat on sales: many are made under a Rule 10b5-1 plan scheduled months in advance, so a sale is not automatically a bearish signal. Insider activity is a noisy input — read it alongside the filings, not on its own.
See also IONS’s full analysis or the market-wide insider trading feed. The tabs above jump to IONS’s other SEC data.
Source: SEC Form 4 filings for IONS, parsed from EDGAR. Transaction prices are as reported in the filing — SEC public-domain data, not market quotes. Values are shares × reported price where both are disclosed; grants and gifts often carry no price. A delayed record of what insiders reported, not a live position or a recommendation.
Research and education only — not financial advice. TENKis not a registered investment adviser or broker-dealer and gives no personalized advice. Every call is impersonal — identical for all users, generated on a schedule from SEC filings plus a delayed/third-party price feed — may be wrong or out of date, and is not a recommendation to buy or sell any security. The operator and an affiliated trading operation may hold or trade the securities TENK rates; see Disclosures. Past performance does not guarantee future results. Do your own research.